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Sven Deferme appointed training & events manager @ BeCRO

Upcoming trainings:

  • Medical Writing, 04-05 June
  • Introduction to statistics, 10-11 May

Check the training calendar.

 
      Publication list      
     

Book chapters

  1. Oral Drug Absorption 2nd Edition (Eds. J. Dressman, C. Reppas) Permeability Measurement. J. Brouwers, S. Deferme, P. Annaert, P. Augustijns (2010) Chapter 10: pp 168-205.
  2. Drug absorption studies - in situ, in vitro, and in silico models (Eds. C. Erhardt, K-J. Kim). In vitro screening models to assess intestinal drug absorption and drug metabolism. S. Deferme, P. Annaert, P. Augustijns (2008) Springer, New York. Chapter 8: pp 182-215.

Peer review articles

  1. Automated blood sampling in drug discovery and development. S. Deferme. theHealth 2011;2:115-116.
  2. Full neurological recovery following cardiac arrest during percutaneous coronary intervention due to accidentally intracoronary administration of ajmaline. M. Gillis. Resuscitation 2011;82 (9):1254 (PMID: 21645955).
  3. (Ex-)smoking asthma patients in general and specialized Belgian practice. Decramer M, Louis R, Joos G, De Vuyst P, Mast B, Mehuys A; On behalf of the Pulmonary Advisory Board. Respir Med. 2011 Aug;105(8):1203-1210 (PMID: 21414762).
  4. Plerixafor in poor stem cell mobilizers: the Belgian compassionate use program. D Selleslag, D Dierickx, D Breems, P Huynh, A Van De Velde, S Meers, E Brouwer, A Mertens. Acta Clinica Belgica 2011; 66(3): 200-204 (PMID: 21837928).
  5. Surgical Treatment of Deeply Infiltrating Endometriosis with Colorectal Involvement.  Meuleman C, Tomassetti C, D’Hoore A, Van Cleynenbreugel B, Penninckx F, Vergote I, D’Hooghe T. Hum Reprod Update. 2011; 17(3):311-326 (PMID: 21233128).
  6. Long-term epidemiology of bacterial susceptibility profiles in adults suffering from febrile neutropenia with haematological malignancy after antibiotic change: a single centre prospective study with 15 years of follow-up. Mebis J, Jansens H, Minalu G, Molenberghs G,  Schroyens WA, Gadisseur AP, Van de Velde A, Vrelust I, Goossens H, Berneman ZN. Infection and Drug Resistance 2010;3:53-61 (PMID: 21694894).
  7. Role and current situation of TURP in patients with elevated PSA. van Renterghem K, van Kerrebroeck P, Van Koeveringe G. Arch Esp de Urologia. 2010 Jul;63(6):411-419 (PMID: 20820080).
  8. Kidney radiofrequency ablation for small renal tumors: oncologic efficacy. Joniau S, Tailly T, Goeman L, Blyweert W, Gontero P, Joyce A. J Endourol. 2010 May;24(5):721-8 (PMID: 20477540).
  9. Antibiotic management of febrile neutropenia: current developments and future directions. Mebis J, Goossens H, Berneman ZN. J. Chemother. 2010 Feb;22(1):5-12 (PMID: 20227985). AWARD WINNING REVIEW
  10. Cefepime and mortality: a real issue? Mebis J, Goossens H, Berneman ZN. Scand J Inf Dis 2010 Jul 42 (6-7):545-548 (PMID: 20144128).
  11. Hypothermic Liver Machine Perfusion With EKPS-1 Solution vs Aqix RS-I Solution: In Vivo Feasibility Study in a Pig Transplantation Model. Vekemans K, Liu Q, Heedfeld V, Van de Vel K, Wylin T, Pirenne J, Monbaliu D. Transplant Proc. 2009 Mar;41(2):617-21 (PMID: 19328939).
  12. A new algorithm in patients with elevated and/or rising prostate-specific antigen level, minor lower urinary tract symptoms, and negative multisite prostate biopsies. van Renterghem K, Van Koeveringe G, Achten R, van Kerrebroeck P. Int Urol Nephrol. 2010;Mar42 (1):29-38. (PMID: 19496018).
  13. Long-term clinical outcome of diagnostic transurethral resection of the prostate in patients with elevated prostate-specific antigen level and minor lower urinary tract symptoms. van Renterghem K, van Koeveringe G, Achten R, van Kerrebroeck P. Urol Int. 2009;83(1):60-65 (PMID: 19641361).
  14. Prospective study of the role of transurethral resection of the prostate in patients with an elevated prostate-specific antigen level, minor lower urinary tract symptoms, and proven bladder outlet obstruction. van Renterghem K, Van Koeveringe G, Achten R, van Kerrebroeck P. Eur Urol. 2008 Dec;54(6):1385-1392 (PMID: 18599187).
  15. Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum. M. Perez de la Cruz Moreno, M. Oth, S. Deferme, F. Lammert, J. Dressman, P. Augustijns (2006) Journal of Pharmacy and Pharmacology, 58:1079-1089 (PMID: 16872555).
  16. Sulfasalazine transport in in-vitro, ex-vivo and in-vivo absorption models: contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts. R. Mols, S. Deferme, P. Augustijns (2005), Journal of Pharmacy and Pharmacology, 57:1565-1573 (PMID: 16354400).
  17. The effect of food components on the absorption of P-gp substrates: a review. S. Deferme, P. Augustijns (2003), Journal of Pharmacy and Pharmacology, 55:153-162 (PMID: 12631407).
  18. P-glycoprotein attenuating effect of human intestinal fluid. S. Deferme, J. Tack, F. Lammert, P. Augustijns (2003), Pharmaceutical Research, 20:900-903 (PMID 12817895).
  19. Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efflux. S. Deferme, J. Van Gelder, A. Kamuhabwa, C. Nshimo, P. de Witte, G. Van den Mooter, P. Augustijns (2003) Phytotherapy Research, 17:459-464 (PMID: 12748979).
  20. Implementation of the Caco-2 cell culture model as a predictive tool for the oral absorption of drugs. In-house validation procedures. F. Ingels, S. Deferme, N. Delbar, M. Oth, P. Augustijns (2002), Journal de Pharmacie de Belgique, 57:153-158 (PMID: 12596572).
  21. Apricot extract inhibits the P-gp-mediated efflux of talinolol. S. Deferme, R. Mols, W. Van Driessche, P. Augustijns (2002) Journal of Pharmaceutical Sciences, 91:2539-2548 (PMID: 12434397).
  22. Inhibitory effect of fruit extracts on P-glycoprotein-related efflux: an in vitro screening. S. Deferme, J. Van Gelder, P. Augustijns (2002) Journal of Pharmacy and Pharmacology, 54:1213-1219 (PMID: 12356275).
  23. Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures. J. Van Gelder, S. Deferme, L. Naesens, E. De Clercq, G. Van den Mooter, R. Kinget, P. Augustijns (2002) Drug Metabolism and Disposition, 30:924-930 (PMID: 12124311).
  24. Intestinal absorption characteristics of the low-solubility thiocarboxanilide UC-781. S. Deferme, J. Van Gelder, F. Ingels, G. Van den Mooter, S. De Buck, J. Balzarini, L. Naesens, E. De Clercq, R. Kinget, P. Augustijns (2002) International Journal of Pharmaceutics, 234:113-119 (PMID: 11839442).
  25. Simulated intestinal fluid as transport medium in the Caco-2 cell culture model. F. Ingels, S. Deferme, E. Destexhe, M. Oth, G. Van den Mooter, P. Augustijns (2002) International Journal of Pharmaceutics, 232:183-192 (PMID: 11790502).
  26. New bis(SATE) prodrug of AZT 5’-monophosphate: in vitro anti-HIV activity, stabillity and potential oral absorption. M. Shafiee, S. Deferme, A.-L. Villard, D. Egron, G. Gosselin, J.-L. Imbach, T. Lioux, A. Pompon, S. Varray, A.-M. Aubertin, G. Van den Mooter, R. Kinget, C. Périgaud, P. Augustijns (2001) Journal of Pharmaceutical Sciences, 90:448-463 (PMID: 11170035).
  27. Increased oral absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism. J. Van Gelder, S. Deferme, P. Annaert, L. Naesens, E. De Clercq, G. Van den Mooter, R. Kinget, P. Augustijns (2000) Drug Metabolism and Disposition, 28:1394-1396 (PMID: 11095573).

Abstracts, posters and proceedings

  1. Mechanical active compression-decompression cardiopulmonary resuscitation (LUCAS) combined with a Boussignac tube during CPR in out-of-hospital cardiac arrest. E. Van Gerven, M. Gillis (2011) European Resuscitation Congress, Malta.
  2. Leesbaarheid van patiëntenbijsluiters. N. Houbrechts, L. Leemans, A. Quanten, S. Deferme (2010) Pharmaceutical Care Symposium, Brussel, Belgium.
  3. Automated blood sampling in mice using a novel micro sampling technique. E.N. Spoelstra, S. Deferme, R. Remie (2006) AFSTAL meeting, Bordeaux, France.
  4. Combination of the candidate microbicide CADA, an entry inhibitor that specifically targets the cellular CD4 receptor, and cellulose acetate 1,2-benzenedicarboxylate has synergistic effects against HIV infection. D. Schols, T. Bell, R. Le Grand, S. Deferme, P. Augustijns, J. Balzarini, K. Vermeire (2006) Microbicides 2006, Cape Town, South Africa.
  5. Utilization of an automated blood sampling device for rat pharmacokinetic studies with direct bioanalysis by Nano-ESI-MS/MS from a silicon chip. M. Lastelle, L. Scholliers, S. De Broux, S. Deferme, J.-M. Dethy (2003) ASMS Meeting, Montreal, Canada.
  6. Modulation of P-gp mediated efflux of cyclosporin A by human intestinal fluid in the Caco-2 system. S. Deferme, J. Tack, P. Augustijns (2002) Biofarmaciedag, Leuven, Belgium.
  7. Absorption enhancement by modulation of intestinal P-gp activity by apricot extract: an in situ study. S. Deferme, R. Mols, G. Van den Mooter, R. Kinget, P. Augustijns (2002) AAPSPharmSci, 4 (4), AAPS Annual Meeting Abstracts W5058, Toronto, Canada.
  8. Attenuation of P-gp modulation by human intestinal fluid: an in vitro study. S. Deferme, J. Tack, P. Augustijns (2002) AAPSPharmSci, 4 (4), AAPS Annual Meeting Abstracts W5060, Toronto, Canada.
  9. Enhanced intestinal absorption of P-gp substrates by apricot extract. S. Deferme, P. Augustijns (2002) GPEN meeting, Ann Arbor, USA.
  10. Modulating effect of apricot extract on P-gp related intestinal efflux. S. Deferme, G. Van den Mooter, R. Kinget, P. Augustijns (2002) APGI-4th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Florence, Italy. Proceedings pp 567-568.
  11. Compatibility of simulated intestinal fluids with the Caco-2 cell culture model. F. Ingels, S. Deferme, E. Destexhe, M. Oth, G. Van den Mooter, P. Augustijns (2002) APGI-4th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Florence, Italy. Proceedings pp 909-910.
  12. Co-administration of fruit extracts as a strategy to improve the intestinal absorption of P-gp substrates. S. Deferme, J. Van Gelder, G. Van den Mooter, R. Kinget, P. Augustijns (2001) AAPSPharmSci, 3 (3), AAPS Annual Meeting Abstracts 3306, Denver, USA.
  13. Evaluation of the mechanism(s) of secretion of the conversion products of tenofovir DF out of Caco-2 cells. J. Van Gelder, S. Deferme, N. Vermeulen, R. Mols, G. Van den Mooter, E. De Clercq, R. Kinget, P. Augustijns (2001) AAPSPharmSci, 3 (3), AAPS Annual Meeting Abstracts 3302, Denver, USA.
  14. Possible modulating effect of a plant extract (Annickia kummeriae) on P-gp related efflux mechanisms. S. Deferme, J. Van Gelder, G. Van den Mooter, P. de Witte, P. Augustijns (2001) Biofarmaciedag, Amsterdam, The Netherlands.
  15. Evidence for multidrug resistance-associated proteins related efflux of the metabolites of tenofovir disoproxil fumarate in Caco-2 monolayers. J. Van Gelder, S. Deferme, N. Vermeulen, R. Mols, G. Van den Mooter, E. De Clercq, L. Naesens, R. Kinget, P. Augustijns (2001) Biofarmaciedag, Amsterdam., The Netherlands.
  16. Influence of Human Intestinal Fluid on the efficacy of P-gp related efflux carriers. S. Deferme, J. Van Gelder, P. Rutgeerts, G. Van den Mooter, R. Kinget, P. Augustijns (2000) Biofarmaciedag, Weesp, The Netherlands.
  17. Different functional activities of biochemical absorption barriers in several absorption models. J. Van Gelder, S. Deferme, E. De Clercq, L. Naesens, G. Van den Mooter, R. Kinget, P. Augustijns (2000) Biofarmaciedag, Weesp, The Netherlands.
  18. Influence of Fasted State Simulated Intestinal Fluid (FASSIF) on the function of P-gp related efflux carriers. S. Deferme, F. Ingels, J. Van Gelder, G. Van den Mooter, R. Kinget, P. Augustijns (2000) AAPSPharmSci, 2 (4), AAPS Annual Meeting Abstracts 3256, Indianapolis, USA.
  19. Absorption enhancement of ester prodrugs by metabolism inhibition. J. Van Gelder, S. Deferme, L. Naesens, E. De Clercq, G. Van den Mooter, R. Kinget and P. Augustijns (2000) AAPSPharmSci, 2(4) AAPS Annual Meeting Abstracts 2165, Indianapolis, USA.
  20. Optimization of experimental conditions to study intestinal transport of the antiviral agent UC-781. S. Deferme, J. Van Gelder, S. De Buck, G. Van den Mooter, J. Balzarini, L. Naesens, E. De Clercq, R. Kinget, P. Augustijns (2000) Biofarmaciedag, Woluwe, Belgium.
  21. Increased oral absorption of the antiviral ester tenofovir disoproxil in rat ileum. J. Van Gelder, S. Deferme, G. Van den Mooter, E. De Clercq, L. Naesens, R. Kinget, P. Augustijns (2000) Biofarmaciedag, Woluwe, Belgium.
  22. Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by strawberry extract results in an increase of its intestinal absorption in rat ileum. J. Van Gelder, S. Deferme, P. Annaert, L. Naesens, E. De Clercq, G. Van den Mooter, R. Kinget, P. Augustijns (1999) AAPSPharmSci, 1 (4), AAPS Annual Meeting Abstracts 4198, San Francisco, USA.
      
           
           
 
 
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